Keith Caulfield answered this question in his "Ask Billboard" column in Billboard Magazine:

'4 MINUTES' OF FAME 

Hi Keith,

Madonna just released her new single "4 Minutes" featuring Justin Timberlake. Do you think American radio stations will play it along with other singles from her upcoming album "Hard Candy?" They shamelessly ignored (her last album) the great "Confessions on a Dancefloor."

This time she collaborated with Timbaland, Pharrell and of course Timberlake. Will this fact entice U.S. radio to put Madonna back onto the airwaves where she belongs?

Micheal Alexander
Boston

Hi Michael,

It seems like the magic combination of Madonna, Justin Timberlake and Timbaland is already working. In "4 Minutes'" first three days of radio release, 60 monitored U.S. radio stations played it seven times or more. That includes WIHT Washington, D.C. (29 spins), KHJZ Houston, Texas (29 spins), WKXS Boston (22 spins) and WHTZ New York (19 spins).

Next week it will likely debut on the CHR/Top 40 airplay chart in our sister publication Radio & Records. It also has a chance of debuting on The Billboard Hot 100 as well.

We'll see if radio stations continue to embrace "4 Minutes" in the coming weeks. It wouldn't be unusual for stations to back off a song after an initial flurry of activity, especially if the song doesn't react well with a station's audience.

On a side note, "4 Minutes" will not only be released as a digital download in the coming weeks, but it will also be granted a physical single release in the U.S. The remixes of "4 Minutes," crafted by Tracy Young, Bob Sinclair and Junkie XL, will be released on CD Maxi, 12" vinyl and of course digitally.

Madonna's "Hard Candy" album drops April 29.

Source: Billboard (found on Drowned Madonna)