Danish journalist Frodi Holm Knudsen interviewed Madonna back in 2005 and asked this interesting question of her:

I had the honour of interviewing Madonna for my Danish newspaper B.T. when 'Confessions On A Dance Floor' was released late 2005.
I asked the Queen of Pop if she would support Hillary Rodham Clinton if she ran for president. At that time nobody knew whether the New York senator would run or not. Madonna answered: 'You bet I would! I wanna be her vice-president!'